Table 2.
Clinical characteristics and echocardiographic parameters in female patients corrected for TOF grouped by number of pregnancies
| 0 pregnancy n=25 (31%) |
1 pregnancy n=19 (24%) |
>1 pregnancy n=36 (45%) |
P value | OR (95% CI) |
P value | |
| Age, years | 29±10 | 38±11 | 40±7 | <0.01 | ||
| Height, cm | 165±7 | 166±4 | 165±7 | 0.55 | ||
| Weight, kg | 67±11 | 63±6 | 69±15 | 0.55 | ||
| HR, bpm | 73±10 | 63±13 | 67±13 | 0.23 | ||
| SBP, mm Hg | 115±9 | 111±14 | 117±10 | 0.84 | ||
| DBP, mm Hg | 71±7 | 65±10 | 71±11 | 0.39 | ||
| QTc duration, ms | 460±30 | 458±30 | 462±33 | 0.83 | ||
| Exercise capacity, W | 127±24 | 131±25 | 133±29 | 0.82 | ||
| NYHA class | 1 (1–3) | 1 (1–2) | 1 (1–3) | 0.53 | ||
| NT-ProBNP, ng/L | 109 (30–372) | 177 (110–836) | 126 (49–558) | 0.50 | ||
| QRS duration, ms | 124 (86–162) | 148 (94–174) | 134 (82–172) | 0.69 | ||
| TOF with VA (n=17) | 1 (4%) | 6 (31%) | 10 (28%) | 0.04 | 2.4 (1.1 to 5.4) | 0.03 |
| RV EDV, mL | 20.5±4.8 | 22.8±4.8 | 21.7±4.1 | 0.25 | ||
| RV ESV, mL | 10.8±2.9 | 12.1±3.7 | 11±2.1 | 0.33 | ||
| RV FAC, % | 47±7 | 46±8 | 49±6 | 0.46 | ||
| RV D3, cm | 7.0±0.7 | 7.6±0.9 | 7.3±0.6 | 0.05 | ||
| PV vel, m/s | 1.9±0.7 | 2.0±0.5 | 1.8±0.5 | 0.65 | ||
| Mod-sev PV reg | 5 (22%) | 3 (15%) | 9 (25%) | 0.76 | ||
| LV MD, ms | 41±10 | 45±11 | 45±16 | 0.59 | ||
| LV GLS, % | −19.0±3.0 | −18.8±3.6 | −18.7±3.2 | 0.95 | ||
| RV MD, ms | 38±12 | 43±16 | 43±13 | 0.41 | ||
| RV GLS, % | −19.2±5.0 | −18.1±3.8 | −19.4±3.2 | 0.54 | ||
| RVOT, cm | 2.9±0.3 | 3.2±0.5 | 2.8±0.5 | 0.07 | ||
| LVEF, % | 57±7 | 56±9 | 54±8 | 0.39 |
Data are presented as mean±SD or median with range, as appropriate; p value from Student’s t-test, Mann-Whitney U, χ2 test or ANOVA as appropriate, and multivariable logistic regression adjusted for age.
DBP, diastolic blood pressure; EDV, end-diastolic volume; ESS, end-systolic strain; ESV, end-systolic volume; GLS, global longitudinal strain; HR, heart rate; LV, left ventricular; LVEF, left ventricular ejection fraction; MD, mechanical dispersion; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association classification; PV, pulmonary valve; RV, right ventricular; RV D3, right ventricular longitudinal diameter; RV FAC, right ventricular fractional area change; RVOT, right ventricular outflow tract; SBP, systolic blood pressure; TOF, tetralogy of Fallot; VA, ventricular arrhythmia.