Table 3.
Association of BDNF p.Val66Met Polymorphism and Obesity Related-Traits and Presence of Comorbidities
| Variables | BDNF p.Val66Met Polymorphism (rs6265) | P-valueδ | ||||
|---|---|---|---|---|---|---|
| n | Non-Carriers (GG) | n | Carriers (GA+AA) | P- value¥ | ||
| Weight (kg) | 166 | 128.0 (112.1; 146.0) | 35 | 131.0 (112.9; 145.5) | 0.749 | 0.857 |
| BMI (kg/m2) | 166 | 47.3 (42.7; 52.8) | 35 | 47.5 (42.3; 54.9) | 0.870 | 0.965 |
| BAI | 164 | 50.3 (44.8; 55.0) | 35 | 49.8 (44.5; 59.1) | 0.732 | 0.650 |
| Waist circumference (cm) | 164 | 135.5 (125.5; 145.5) | 35 | 139.0 (130.0; 152.0) | 0.161 | 0.043 |
| Hip circumference (cm) | 164 | 141.7 (133.0; 152.0) | 35 | 147.0 (135.0; 152.0) | 0.530 | 0.180 |
| WHR | 164 | 0.95 (0.90; 0.99) | 35 | 0.98 (0.93; 1.03) | 0.176 | 0.286 |
| SBP (mm Hg) | 90 | 132.0 (120.0; 149.0) | 19 | 126.0 (110.0; 140.0) | 0.683 | 0.935 |
| DBP (mm Hg) | 90 | 87.5 (78.0; 97.2) | 19 | 82.0 (72.0; 91.0) | 0.873 | 0.881 |
| Glucose (mg/dL) | 122 | 96.0 (89.7; 109.0) | 27 | 97.0 (89.0; 104.0) | 0.672 | 0.685 |
| Cholesterol total (mg/dL) | 137 | 190.0 (162.0; 217.0) | 31 | 187.0 (170.0; 214.0) | 0.538 | 0.476 |
| HDL-cholesterol (mg/dL) | 137 | 45.0 (40.0; 52.0) | 31 | 49.0 (44.0; 57.0) | 0.008 | 0.008 |
| LDL-cholesterol (mg/dL) | 134 | 116.0 (95.7; 132.2) | 30 | 116.0 (97.2; 133.7) | 0.563 | 0.456 |
| Triglycerides (mg/dL) | 137 | 125.0 (94.5; 167.0) | 31 | 106.0 (77.0; 135.0) | 0.177 | 0.128 |
| Hemoglobin glycated (%) | 88 | 5.60 (5.10; 6.27) | 22 | 5.80 (4.87; 7.15) | 0.379 | 0.345 |
| CRP (mg/dL) | 87 | 1.04 (0.56; 1.52) | 22 | 1.12 (0.55; 1.89) | 0.509 | 0.366 |
| Leptin (pg/mL) | 79 | 2645.4 (1903.4; 3354.6) | 17 | 2627.0 (2370.0; 3740.2) | 0.407 | 0.290 |
| MCP1 (pg/mL) | 79 | 239.8 (127.9; 361.5) | 17 | 327.1 (236.2; 437.1) | 0.015 | 0.041 |
| PAI-1 (pg/mL) | 79 | 24,940.2 (16,771.7; 31,045.5) | 17 | 34,083.5 (17,798.7; 39,676.8) | 0.104 | 0.252 |
| Resistin (pg/mL) | 79 | 7952.9 (5140.7; 10,504.1) | 17 | 10,488.3 (6901.7; 14,033.8) | 0.028 | 0.115 |
| Period of obesity onset | ||||||
| Childhood | 166 | 101 (60.8) | 35 | 21 (60.0) | 0.665 | 0.632 |
| Adolescence/youth | 65 (39.2) | 14 (40.0) | ||||
| Metabolic syndrome | ||||||
| Yes | 128 | 98 (76.6) | 30 | 16 (53.3) | 0.009 | 0.007 |
| No | 30 (23.4) | 14 (46.7) | ||||
| Hypertension | ||||||
| Yes | 158 | 106 (67.1) | 35 | 22 (62.8) | 0.545 | 0.569 |
| No | 52 (32.9) | 13 (37.1) | ||||
Notes: P-value for differences between BDNF p.Val66Met polymorphism carriers and non-carriers. P-value¥ was adjusted for age and gender (model 1). P-valueδ was adjusted for age, gender, exercises habits, smoking status and BMI (except for BMI and body weight) [model 2]. Bold font indicates statistical significance.
Abbreviations: BAI, body adiposity index; BMI, body mass index; CRP, C-reactive protein; DBP, diastolic blood pressure; HDL-cholesterol, high-density lipoprotein-cholesterol; LDL-cholesterol, low-density lipoprotein-cholesterol; MCP1, monocyte chemoattractant protein-1; na, not available; PAI-1, plasminogen activator inhibitor-1; SBP, systolic blood pressure; WHR, waist–hip ratio.