Skip to main content
. 2021 Jan 7;9(1):e001466. doi: 10.1136/jitc-2020-001466

Figure 7.

Figure 7

Schematic diagram showing the role of the AIM2 inflammasome and α1-adrenergic receptor (α1-AR) in the release of IL-1β and macrophage-mediated immunosuppression triggered by CAR-T treatment. CAR-T, chimericantigen receptor T; CRS, cytokine releasesyndrome; ds DNA, double-stranded DNA; IDO, indoleamine 2,3-dioxygenase; PD-L1, programmed cell death-ligand 1.