Figure 7.
Schematic diagram showing the role of the AIM2 inflammasome and α1-adrenergic receptor (α1-AR) in the release of IL-1β and macrophage-mediated immunosuppression triggered by CAR-T treatment. CAR-T, chimericantigen receptor T; CRS, cytokine releasesyndrome; ds DNA, double-stranded DNA; IDO, indoleamine 2,3-dioxygenase; PD-L1, programmed cell death-ligand 1.