Table 2.
Univariate and Multivariate Analysis for Overall Survival in ICC Patients
| Univariate Analysis P value |
Overall Survival HR (95% CI) | P Value | Recurrence-Free Survival HR (95% CI) | P Value | |
|---|---|---|---|---|---|
| Age (years) | |||||
| <60 | 0.082 | 1 | 0.726 | 1 | 0.496 |
| ≥60 | 3.255(0.756–14.008) | 1.661(0.385–7.177) | |||
| Gender | |||||
| Male | 0.942 | 1 | 1 | ||
| Female | |||||
| Hepatitis | |||||
| Negative | 0.350 | 1 | 1 | ||
| Positive | |||||
| Cholelithiasis | |||||
| Present | 0.445 | 1 | 1 | ||
| Absent | |||||
| CA19-9 (U/mL) | |||||
| >37 | 0.278 | 1 | 1 | ||
| ≤37 | |||||
| Tumor diameter (cm) | |||||
| <5 | 0.073 | 1 | 0.674 | 1 | 0.601 |
| ≥5 | 1.331(0.352–5.033) | 0.676(0.156–2.933) | |||
| Differentiation | |||||
| Well | 0.268 | 1 | 1 | ||
| Moderately | |||||
| Poorly | |||||
| Perineural invasion | |||||
| Present | 0.101 | 1 | 1 | ||
| Absent | |||||
| Vascular invasion | |||||
| Present | 0.006* | 1 | 0.726 | 1 | 0.466 |
| Absent | 0.735(0.132–4.102) | 0.546(0.107–2.782) | |||
| Lymphoid metastasis | |||||
| Present | 0.040* | 1 | 0.436 | 1 | 0.929 |
| Absent | 0.457(0.064–3.281) | 0.911(0.117–7.074) | |||
| Clinical stage | |||||
| TNM I/II | 0.003* | 1 | 0.548 | 1 | 0.723 |
| TNM III | 0.695(0.212–2.280) | 1.231(0.390–3.883) | |||
| Immunoscore (IS) | |||||
| IS0-1 | 0.033* | 1 | 0.048* | 1 | 0.105 |
| IS2 | 0.176(0.031–0.981) | 0.248(0.046–1.341) | |||
| IS3-4 | |||||
Note: *P<0.05.
Abbreviations: CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19–9.