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. 2021 Jan 6;16:47–60. doi: 10.2147/IJN.S282154

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© 2021 Wei et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

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In vivo therapeutic efficiency of C57 mice with Hepa1-6 xenograft model was treated with RADA16-I, EMS or RADA16-I-EM. (A) Illustration of RADA16-I encapsulated EM. (B) Illustration of RADA16-I/EMS/RADA16-I-EM for the intra-tumor administration of tumor-bearing mice. (C) Body weight change in various groups. (D) Tumor volume change in various groups. (E) The images of dissected tumor tissues. (F) Tumor weight was recorded after the last injection. *P<0.01 vs PBS; ^#P<0.05 vs EMS or PBS. Data are presented as mean ± SD (n = 8).

Abbreviation: EMS, emodin water suspension.