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. 2021 Jan 6;14:1–13. doi: 10.2147/OTT.S280912

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© 2021 He et al.

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Effects of long noncoding RNA DCST1 antisense RNA 1 (CCDC144NL-AS1) downregulation on the proliferation, apoptosis, migration, and invasion of HOS and Saos-2 cells are largely reversed by restoring high-mobility group AT-hook 2 (HMGA2) expression. (A) Western blotting was conducted to determine HMGA2 protein expression in pc-HMGA2-transfected or pcDNA3.1-transfected HOS and Saos-2 cells. (B–E) CCDC144NL-AS1-depleted HOS and Saos-2 cells were treated with pc-HMGA2 or pcDNA3.1 plasmids and subjected to cell proliferation, apoptosis, migration, and invasion analyses using the Cell Counting Kit 8 (CCK-8) assay, flow cytometric analysis, and Transwell migration and invasion assays, respectively. *P < 0.05 and **P < 0.01.