Figure 11.

Schematic of model showing how attachment and/or invasion of epithelial cells by adherent-invasive E coli (strain LF82 depicted) can lead to fragmentation of the mitochondrial network via DRP1 activation, and possibly loss of OPA1-L, and mitochondrial disruption as defined by movement of cytochrome C from mitochondria to the cytosol. Infection with E coli–LF82 was not accompanied by evidence of caspase-3 activation. The cell stress experienced results in reduced epithelial function and may have implications for cell activation (ie, alarmin release) and viability (red lines indicate pathway supported by data in the current study).