Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 24;47(2):732–740. doi: 10.3892/ijmm.2020.4833

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Zou et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

The expression level of inflammasome NLRP3 is upregulated via the activation of the ASK1/p38 signaling axis. (A) The protein expression levels of AKS1 and p38 were upregulated in the DR animal group. (B) The results of the HG-induced HRMEC group were similar to those of the DR animal group. (C) The NLPR3, IL-6, TNF-α, IL-1β and VEGF protein expression levels were inhibited by (C) ASK1 inhibitor and (D) p38 inhibitor. NLRP3, NLR family pyrin domain containing 3; ASK1, apoptosis signal-regulating kinase 1; DR, diabetic retinopathy; HG, high glucose; HRMEC, human retinal microvascular endothelial cell; IL, interleukin; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; Ctrl, control.