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. 2020 Dec 16;47(2):633–642. doi: 10.3892/ijmm.2020.4820

Figure 5.

Figure 5

miR-882 targets Rev-erbα. (A) Venn diagram of the miRNAs overlapping with Rev-erbα from three different databases (TargetScan, miRDB and DIANA). miR-882 was the only miRNA identified in all three databases that potentially regulated Rev-erbα expression. (B) Transfection efficiency of miR-882 mimic and inhibitors. (C) Rev-erbα protein expression after transfection with miR-882 mimics, inhibitors and corresponding NCs. (D) Binding sites for miR-882 and Rev-erbα. (E) Luciferase activity in 293T cells co-transfected with miR-882 mimic and Rev-erbα WT or MUT 3′-untranslated region. Data are represented as the mean ± SD (n=3). *P<0.05 and **P<0.01. miRNA/miR, microRNA; NC, negative control; WT, wild-type; MUT, mutant; Rev-erbα/NR1D1, nuclear receptor subfamily 1 group D member 1.