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. 2020 Dec 16;47(2):633–642. doi: 10.3892/ijmm.2020.4820

Figure 6.

Figure 6

Melatonin downregulates miR-882 expression in RANKL-induced Raw264.7 cells, whereas the overexpression of miR-882 promotes osteoclasto-genesis in Raw264.7 cells. (A) miR-882 expression in Raw264.7 cells cultured for 7 days with RANKL (100 ng/ml) and M-CSF (30 ng/ml) in the presence of varying concentrations (0.1 or 1 µmol) of melatonin. (B) Cathepsin K expression after transfection with miR-882 mimics, inhibitors and corresponding NCs. Data are represented as the mean ± SD (n=3). *P<0.05 and **P<0.01. RANKL, receptor activator of nuclear factor-κB ligand; M-CSF, macrophage colony-stimulating factor; miR, microRNA; NC, negative control.