Association of lymph node status and Breslow depth with worse prognosis in melanoma patients. (A) Tumor infiltration to the regional lymph nodes were associated with shorter overall survival (means were 22.14 and 28.19 months in positive and negative regional lymph nodes, respectively; Log-rank Mantel-Cox test, P = 0.001). (B) Breslow thickness more than 4 mm was associated with worse overall survival (means were 23.04 and 30.59 months in T4 and T1-3, respectively; Log-rank Mantel-Cox test, P = 0.047). (C) In nodular melanoma, Breslow thickness more than 4 mm was associated with worse overall survival (means were 19.4 and 31.2 months in T4 and T1-3, respectively; Log-rank Mantel-Cox test, P = 0.006).