Table 2.
Odds ratios and 95% confidence intervals of different clinicopathological variables to the risk of progression into distant metastasis using univariable and multivariable logistic regression.
| Variables |
Category |
Melanoma (total) |
Cutaneous melanoma |
Mucosal melanoma |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95%CI) |
P value |
OR (95%CI) |
P-value |
OR (95%CI) |
P value |
OR (95%CI) |
P value |
OR (95%CI) |
P value |
OR (95%CI) |
P value |
|||
| Univariate | Multivariate | Univariate | Multivariate | Univariate | Multivariate | |||||||||
| Age (years) | ≤65 | ref | ref | ref | ref | ref | ref | ref | ||||||
| >65 | 0.762 (0.308–1.888) | 0.463 | 0.708 (0.245–2.047) | 0.524 | 0.497 (0.148–1.664) | 0.257 | 0.304 (0.461–2.017) | 0.304 | 1.250 (0.307–5.085) | 0.755 | 1.504 (0.248–9.130) | 0.658 | ||
| Sex | Male | 1.171 (0.662–2.073) | 0.578 | 0.546 (0.196–1.521) | 0.247 | 2.105 (0.609–7.246) | 0.996 | 0.252 (0.052–1.229) | 0.088 | 0.960 (0.239–3.853) | 0.954 | 0.938 (0.204–4.317) | 0.935 | |
| Female | ref | ref | ref | ref | ref | ref | ref | ref | ref | ref | ||||
| Histological type | Nodular | 1.155 (0.749–2.798) | 0.938 | 1.089 (0.342–3.468) | 0.886 | 0.504 (0.086–2.964) | 0.448 | 0.512 (0.217–1.712) | 0.448 | – | – | – | – | |
| Other | ref | ref | ref | ref | ||||||||||
| Breslow thickness | >4 mm | 1.067 (0.398–2.858) | 0.503 | 1.305 (0.373–4.567) | 0.677 | 2.557 (0.277–28.747) | 0.447 | 0.857 (0.222–3.315) | 0.690 | 1.238 (0.266–5.767) | 0.758 | |||
| ≤4 mm | ref | ref | ||||||||||||
| Node | Positive | 1.201 (0.496–2.906) | 0.684 | 1.236 (0.288–5.309) | 0.775 | 1.149 (0.190–6.957) | 0.880 | 2.702 (0.602–12.048) | 0.195 | 0.909 (0.143–5.781) | 0.920 | 0.369 (0.032–4.225) | 0.432 | |
| Negative | ref | ref | ref | ref | ref | ref | ref | ref | ||||||
| Ulceration | Yes | 3.003 (1.010–9.090) | 0.05 | 6.711 (1.745–25.6) | 0.06 | 10.00 (2.012–50.00) | 0.005 | 2.294 (0.613–8.587) | 0.218 | – | – | – | – | |
| No | ref | ref | ref | ref | ref | ref | – | – | – | |||||
| Stage (AJCC VIII) | Early (I-II) | ref | ref | ref | ref | ref | ref | ref | – | – | ||||
| Advanced (III) | 0.905 (0.319–2.562) | 0.85 | 0.510 (0.114–2.286) | 0.510 | 0.947 (0.242–3.715) | 0.938 | ref | ref | 1.000 (1.000) | 1.000 | 0.279 (0.025–3.047) | 0.295 | ||
| Location | Acral, extremities | 1.534 (0.630–3.734) | 0.346 | 2.669 (0.625–11.656) | 0.185 | 1.652 (0.139–19.654) | 0.782 | 0.726 (0.032–16.305) | 0.40 | – | – | – | – | |
| Trunk, head and neck | ref | ref | ref | ref | ref | ref | ref | |||||||
| Diameter | ≤6 mm | ref | ref | ref | ref | ref | ref | ref | ||||||
| >6 mm | 2.844 (0.304–26.657) | 0.663 | 5.080 (0.370–69.827) | 0.227 | 0.792 (0.036–13.501) | 0.872 | 2.124 (0.045–100.013) | 0.701 | – | – | – | – | ||