Table 3.

Odds ratios and 95% confidence intervals of variables associated with specific distant organ metastases.

Variables		Pulmonal metastasis		Pleural metastasis			Bone metastasis		Liver metastasis		Brain metastasis
	Category	OR (95%CI)	P value	OR (95%CI)		P-value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Age (years)	≤65	ref					ref		ref		ref	ref
	>65	0.463 (0.117–1.182)	0.271	1.677 (0.442–6.354)		0.447	1.020 (0.165–6.290)	0.983	0.102 (0.010–1.002)	0.05	–	–
Sex	Male	0.795 (0.218–2.896)	0.728	0.580 (0.159–2.113)		0.409	0.602 (0.129–2.806)	0.518	0.211 (0.044–1.000)	0.05	–	–
	Female	ref	ref	ref		ref	ref		ref	ref
Histological type	Nodular	0.709 (0.152–3.301)	0.661	0.360 (0.084–1.543)		0.169	11.557 (1.442–92.608)	0.021	5.236 (0.726–37.76)	0.101	1.414 (0.040–50.26)	0.849
	Other	ref		ref			ref		–		ref	ref
Breslow thickness	>4 mm	0.505 (0.087–2.916)	0.503	2.119 (0.421–10.670)		0.363	6.806 (0.824–56.206)	0.075	2.531 (0.393–16.292)	0.328	0.267 (0.009–7.600)	0.440
	≤4 mm	ref		ref
Node	Positive	3.199 (0.461–22.217)	0.240	0.489 (0.078–3.072)		0.446	0.094 (0.004–2.083)	0.135	2.010 (0.242–16.717)	0.518	–	–
	Negative	ref	ref			ref	ref		ref	ref
Ulceration	Yes	3.257 (0.746–14.084)	0.116	0.480 (0.097–2.384)		0.370	–	-	16.95 (1.379–200)	0.027	4.100 (0.204–82.53)	0.357
	No	ref	ref	ref		ref	ref	ref	ref		–
Stage (AJCC VIII)	Early (I-II)	ref	ref	ref			ref		ref	ref
	Advanced (III)	0.247 (0.035–1.730)	0.159	0.532 (0.086–3.313)		0.499	5.686 (0.186–173.907)	0.319	0.269 (0.022–3.276)	0.269	–	–
Location	Acral, extremities	7.181 (1.045–49.35)	0.045	3.855 (0.615–24.186)		0.150	0.527 (0.038–7.248)	0.632	0.349 (0.029–4.121)	0.349	–	–
	Trunk, head and neck	ref	ref	ref		ref	ref		ref	ref