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. 2020 Dec 2;47(2):533–546. doi: 10.3892/ijmm.2020.4806

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Copyright: © Grossi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Determination of EV preparation purity from protein contaminants using CONAN assay. Normalized Aggregation Index (AI) of disperse gold nanoparticles (AuNPs), LEVs (green), MEVs (blue), SEVs (brown) and pure SEVs (grey) fractions are shown in the graph for either controls (A) and PD patients (B). AI decreases along with the change of the solution color from red to blue (as indicated by the color scale) and is inversely proportional to the purity of preparation. Dotted line represents the 20% of AuNPs AI. LEVs, large extracellular vesicles; MEVs, medium extracellular vesicles; SEVs, small extracellular vesicles.