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. 2021 Jan 11;379(1):4. doi: 10.1007/s41061-020-00318-2

Table 9.

HCV replicon activity of phosphoramidate prodrugsgraphic file with name 41061_2020_318_Strb_HTML.jpg

Compound R EC50 (1b, μM) CC50 (Huh-7, μM)
5 iso-Pr 1.45 > 89
6 Me 1.37 > 89
7 Et 1.05 > 89
8 (S)-sec-Bu 0.23 > 89
9 (R)-sec-Bu 0.98  > 89
10 t-Bu > 89 > 89
11 cyc-pentyl 0.45 > 89
12 neo-pentyl 0.18 85
13 2-EtBu 0.44 35
14 Bn 0.33 63