Table 7.
Association of CYP4F2, APOE and CYP2A6 SNPs with INR treatment outcome
Gene | SNP ID | Genotype | Initiation INR | Overall P-value* | Maintenance INR | Overall P-value* |
---|---|---|---|---|---|---|
CC | 2.47 [0.77] | 2.69 [0.38] | ||||
CYP4F2 | rs2108622 | CT | 2.50 [0.81] | 0.34 | 2.70 [0.41] | 0.97 |
TT | 2.27 [0.61] | 2.69 [0.35] | ||||
CC | 2.45 [0.75] | 2.71 [0.39] | ||||
APOE | rs74125 | TC | 2.37 [0.79] | 0.29 | 2.49 [0.34] | 0.06 |
TT | 1.30 […...] | |||||
GG | 2.45 [0.83] | 2.69 [0.43] | ||||
APOE | rs405509 | GT | 2.43 [0.78] | 0.82 | 2.69 [0.36] | 0.99 |
TT | 2.51 [0.69] | 2.70 [0.40] | ||||
CYP2A6 | rs1801272 | AA | 2.44 [0.77] | 0.09 | 2.71 [0.38] | 0.02 |
TA | 3.02 [0.81] | 2.25 [0.44] |
*One-way ANOVA test with P-value < 0.05 is considered significant, Mean Standard deviation in square brackets.