Fig. 3.

In vivo release of doxycycline hyclate from the GRS in a swine model. (A) Representative photograph of a GRS after assembly of drug pills along a nitinol wire before deployment in vivo. (B) Representative photo of a retrieved GRS after 28 days in vivo in a swine model. (C) Left: Concentration-time profiles of doxycycline hyclate in serum after administering a single dose of 100 mg (n = 3). Right: Concentration-time profiles of doxycycline hyclate in serum after administering the GRS, which had 10 g of drug across four formulations (n = 3; fig. S5). (D) Area under the curve (AUC) and the duration of drug release for a single dose compared to the formulations of the GRS administered in vivo, with the mean value and SD reported for n = 3 samples in each group.