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. 2021 Jan 1;12(4):976–987. doi: 10.7150/jca.50234

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Effect of JMJD8 on the expression of EMT-related proteins and key molecules in the PI3K/AKT signaling pathway. (A) Western blotting results showing the expression levels of EMT-related proteins in A549 and H1299 cells. (B) JMJD8 overexpression in A549 and H1299 cells resulted in the upregulation of phosphorylated AKT and PI3Kp85α levels. Conversely, JMJD8 knockdown decreased the level of phosphorylated AKT and PI3Kp85α levels, however, the expression of key molecules in the RAS/MAPK/ERK signaling pathway showed no significant changes.