Figure 1.

Interaction between chimeric antigen receptor (CAR) T-cell and cancer cell. T-cells harvested from patients are genetically modified using viral or non-viral systems to produce the CAR, which includes an antibody-like surface domain, transmembrane domain and intracellular signaling domains. CAR T-cells interact with tumor antigens on cancer cells by using their extracellular surface domain, linked to intracellular costimulatory and signaling domains to amplify the immune response against tumor cells. Furthermore, pro-inflammatory cytokines and chemokines are produced and participate in the eradication of cancer cells.