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Schematic diagram of CDH11 mediated cell adhesion. The extracellular domains of CDH11 have five repeat sequences, called EC1-EC5. The cytoplasmic tail controls the function of CDH11. It can interact with p120ctn, α-catenin, β-catenin to form complexes. And the compound can further interact with α-actinin, vinculin, ZO-1 and the actin cytoskeleton. Abbreviations: ZO-1: zonula occludens-1; EC1-5: five extracellular domains of cadherin-11; p120: p120 catenin.
