Table 3.
Univariate and multivariate analyses of factors associated with overall survival (OS)
| Factors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | P value | HR | 95%CI | P value | |
| Gender | ||||||
| Female | 1.000 | 1.000 | ||||
| Male | 1.234 | 0.7701-1.976 | 0.411 | 1.042 | 0.611-1.777 | 0.880 |
| Age (years) | ||||||
| <60 | 1.000 | 1.000 | ||||
| ≥60 | 1.847 | 1.270-2.685 | 0.001 | 2.153 | 1.452-3.192 | <0.001 |
| Location | ||||||
| Upper | 1.000 | 1.000 | ||||
| Middle | 0.8534 | 0.4595-1.585 | 0.596 | 0.934 | 0.507-1.720 | 0.826 |
| Lower | 1.097 | 0.6117-1.967 | 0.759 | 1.655 | 0.862-3.180 | 0.130 |
| Histological grade | ||||||
| 1 | 1.000 | 1.000 | ||||
| 2 | 1.991 | 1.300-3.050 | <0.001 | 2.252 | 1.436-3.534 | <0.001 |
| 3 | 2.135 | 1.104-4.130 | 0.004 | 2.488 | 1.420-4.358 | 0.001 |
| pT status | ||||||
| T1/T2 | 1.000 | 1.000 | ||||
| T3/T4 | 2.184 | 1.499-3.180 | <0.001 | 1.530 | 0.966-2.423 | 0.070 |
| pN status | ||||||
| N0 | 1.000 | 1.000 | ||||
| N1 | 1.757 | 0.9385-3.289 | 0.031 | 1.134 | 0.544-2.362 | 0.738 |
| N2 | 3.265 | 1.429-7.459 | <0.001 | 1.794 | 0.691-4.658 | 0.230 |
| N3 | 4.968 | 1.409-17.52 | <0.001 | 2.916 | 1.082-7.857 | 0.034 |
| TNM stage | ||||||
| Ⅰ | 1.000 | 1.000 | ||||
| Ⅱ | 2.457 | 1.479-4.080 | 0.003 | 2.930 | 1.398-6.139 | 0.004 |
| Ⅲ | 4.876 | 2.765-8.599 | <0.001 | 3.618 | 1.156-11.322 | 0.027 |
| TSR | ||||||
| stromal-low | 1.000 | 1.000 | ||||
| stromal-high | 2.044 | 1.411-2.962 | <0.001 | 2.531 | 1.657-3.867 | <0.001 |
Bold indicates values with a significant difference P<0.05. HR: hazard ratio