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Intracellular biogenesis and secretion of extracellular vesicles. A: The process of exosome formation begins with early-sorting endosomes (ESE) formed by endocytosis on the surface of plasma membranes. Subsequently, ESE matures to generate a late endosome (LSE)/multivesicular body (MVB) and exosomes are released into the extracellular space by fusion of MVBs. B: Exosomes interact with target cells via receptors, fusion with plasma membrane, endocytosis, or release of their cargo.
