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. 2021 Jan 1;11(5):2247–2262. doi: 10.7150/thno.51666

Figure 1.

Figure 1

Blockade of NMDAR by Mem prevents HFD-induced obesity phenotypes in mice. (A) C57BL/6 mice received intraperitoneal injections of Mem from week 1 to week 12 with HFD or normal chow diet. (B) Glutamate concentration in serum from mice fed with HFD for 12 weeks (n = 12). (C) Representative images of mice after HFD feeding for 12 weeks. (D) Growth curve of mice fed with HFD or normal chow diet for 12 weeks (n = 12). Compare to the Control group, **P < 0.01; ***P <0.001. Compare to the HFD group, #P < 0.05; ###P <0.001. (E-F) Determination of food intake of mice fed with HFD or normal chow diet for 12 weeks (n = 6). (G) H&E staining of SubQ fat tissue from mice fed with HFD or normal chow diet for 12 weeks (Scale bars = 50 μm). (H-M) Determination of SubQ and Epi fat weight and liver weight from mice fed with HFD or normal chow diet for 12 weeks (n = 8). *P < 0.05; **P <0.01; ***P <0.001. All data are presented as the mean ± SEM.