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. 2021 Jan 1;11(5):2247–2262. doi: 10.7150/thno.51666

Figure 2.

Figure 2

Blockade of NMDAR by Mem attenuates insulin resistance glucose tolerance of mice fed with HFD. (A) Measurement of fasting blood glucose of mice fed with HFD or normal chow diet for 12 weeks (n = 8). (B) Measurement of serum insulin level of mice fed with HFD or normal chow diet for 12 weeks (n = 6). (C-D) Measurement of blood glucose during IGTT of mice fed with HFD or normal chow diet for 12 weeks (n = 8). Compare to the Control group, *P < 0.05; ***P <0.001. Compare to the HFD group, #P < 0.05. (E-F) Measurement of blood glucose during the IITT of mice fed with HFD or normal chow diet for 12 weeks (n = 6). Compare to the Control group, *P < 0.05; **P <0.01. Compare to the HFD group, #P < 0.05; ##P <0.01. (G-H) Representative immunofluorescence staining images of pancreases and determination of islet size of mice fed with HFD or normal chow diet for 12 weeks (Insulin: red, DAPI: blue, n = 8). *P < 0.05; **P <0.01; ***P <0.001. All data are presented as the mean ± SEM.