Figure 1.

STK39 up-regulation in HCC tissues is regulated by SP1. (A) The analysis of STK39 gene expression in human HCC tissues and matched normal tissues. (B) STK39 protein expression in non-tumorigenic MIHA, LO2 and various HCC cell lines was assessed by immunoblotting. (C) The expression and phosphorylation of STK39 in human HCC tissues (T) and matched normal tissues (N) were assessed by immunoblotting. (D) Representative images of STK39 expression in HCC tissues by IHC staining, scale bar, 50 µm. (E) The elevated expression of STK39 and phosphorylation levels of STK39 were also shown in the integrated proteogenomic characterization of HBV related HCC. (F) The expression of STK39 was associated with the survival of HCC patients using OncoLnc-linked TCGA database. Data are shown as mean ±SEM. ***p<0.001.