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. 2021 Jan 1;11(5):2349–2363. doi: 10.7150/thno.48407

Figure 5.

Figure 5

The in vivo therapeutic abilities of EMNP in osteomyelitis model. (A) Illustration of osteomyelitis treatment process. (B) Biocompatibility of EMNP detected by CCK-8 assay. (C) Photos and (D) quantification of the bacterial colony of the femur bone tissues treated with NP, CMNP and EMNP with ultraviolet irradiation after 5 days (scale bar = 2 cm). (E) H&E staining of inflammatory area from femur after treatment in 5 days (black dotted line showed the inflammatory infiltration area). (scale bar = 50 μm). (F) Quantitative analysis of the immune cells numbers in inflammatory sites. (G) Masson staining of bone repairing area after 4 weeks (black dotted box showed the origin bone defect area, scale bar = 100 μm). (H) Quantitative analysis of new bone area of black dotted line in (F) (*p < 0.05, **p < 0.01, ***p < 0.0001).