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. 2021 Jan 1;11(5):2048–2057. doi: 10.7150/thno.53506

Table 1.

Promising therapeutic targets in tumor metabolism

Cellular Process Target Effects of Silencing
Glycolysis PDK1 Reverses Warburg effect, promoting apoptosis and reducing tumor invasiveness 10.
Fatty Acid Oxidation CPT-1 Etomoxir inhibits fatty acid oxidation and promotes intracellular ROS accumulation 19.
Urea Cycle CAD Reduces proliferation of ASS1 silenced cells
Glutamate-Glutamine GRIN NMDA receptor antagonist MK508 reduces tumor growth 40.
Autophagy ATG7 Inhibits autophagosome formation 61.