Table 2.

Univariate analysis of risk factors associated with 18-month mortality in the derivation cohort (N = 315)

	HR	95% CI	p value
Demographics
Age, years	1.03	1.01–1.05	0.005
Gender (women)	0.97	0.65–1.44	0.87
Nursing home resident	1.35	0.87–2.10	0.17
Comorbidities
Coronary artery disease	1.33	0.76–2.30	0.30
Heart failure	1.91	1.23–2.96	0.004
Diabetes mellitus	1.15	0.72–1.85	0.54
Cerebrovascular disease	1.03	0.64–1.67	0.90
Dementia	2.97	1.87–4.71	0.000
COPD	1.14	0.70–1.85	0.57
Cancer	1.38	0.88–2.16	0.15
Chronic kidney disease	1.21	0.99–1.47	0.06
Liver disease	1.59	1.21–2.08	0.001
Charlson comorbidity score	1.21	1.11–1.32	0.000
Active smoker	1.35	0.67–2.73	0.85
Severity of pneumonia
CURB-65	1.86	1.42–2.41	0.000
PSI class	1.77	1.40–2.25	0.000
Vital parameters at admission
Systolic blood pressure (mmHg)	0.99	0.99–1.00	0.94
Heart rate (bpm)	1.00	0.99–1.01	0.10
Respiratory rate	1.04	0.99–1.09	0.08
Body temperature (°C)	0.75	0.62–0.92	0.006
Arterial oxygen saturation (%)	0.98	0.93–1.02	0.25
Altered mental status at admission (%)	3.23	2.16–4.82	0.000
Bilateral involvement at Rx (%)	1.03	0.65–1.65	0.88
Laboratory data at admission
Haemoglobin (g/L)	0.85	0.77–0.95	0.006
Haematocrit (%)	0.98	0.95–1.03	0.42
RDW (%)	1.18	1.09–1.28	0.000
eGFR (ml/min)	0.991	0.984–0.998	0.01
BUN (mg/dL)	1.02	1.01–1.03	0.000
C-reactive protein (mg/dL)	0.997	0.996–0.999	0.03
Procalcitonin (mg/L)	0.984	0.951–1.017	0.34
Sodium (mEq/L)	1.02	0.99–1.05	0.15
Glucose (mg/dL)	1.00	0.99–1.00	0.32

Data are expressed as Number (Percentage), mean ± standard deviation or median (25–75% percentiles) as appropriate

BUN Blood Urea Nitrogen, COPD chronic obstructive pulmonary disease, eGFR estimated glomerular filtration rate, PSI Pneumonia Severity Index, RDW red cell distribution width

^*Data available for N = 283