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. 2021 Jan 11;22:46. doi: 10.1186/s12864-020-07326-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The immature F. hepatica parasites display a different profile of gene expression compared with F. gigantica. a Venn diagram representing the number of significantly enriched GO terms shared between the F. hepatica immature flukes at 21 days post infection (F. hepatica_21dpi) and the F. gigantica immature flukes at 42- and 70-days post infection (F. gigantica_42dpi; F. gigantica_70dpi). The numbers in brackets depict the total number of enriched GO terms per dataset. Description of the GO terms is presented in Additional file 4. b Graphical representation of the top 150 abundantly transcribed genes from F. hepatica immature flukes at 21 days post infection (F. hepatica_21dpi) and the F. gigantica immature flukes at 42- and 70-days post infection (F. gigantica_42dpi; F. gigantica_70dpi). Data is represented as the percentage abundance relative to total gene transcription for each dataset, with genes grouped by gene family where possible. c-f Schematic representation of the gene ontology (GO) enrichment analysis using REVIGO based on molecular function and biological processes highlighting the enriched GO terms that play a role as the parasite grows and develops. c Molecular function GO terms within the F. hepatica immature transcriptome. d Biological process GO terms within the F. hepatica immature fluke transcriptome. e Molecular function GO terms within the F. gigantica immature fluke transcriptomes. f Biological process GO terms within the F. gigantica immature transcriptomes. The bubble colour indicates the log value of the FDR adjusted p value and the circle size (plot size) represents the frequency of the GO term within the gene ontology annotation database (GOA; more general terms represented by larger plot size)