FIGURE 2.

Fenofibrate ameliorates subretinal fibrosis in very low–density lipoprotein receptor (Vldlr) ^−/− mice. (A) Representative retinal images of H&E staining from Vldlr ^−/− mice fed with control chow [Vldlr ^−/− + vehicle (VEH)] or fenofibrate chow (Vldlr ^−/− + feno). (B) Representative images of Masson staining of collagen deposition in Vldlr ^−/− mice fed with control chow (Vldlr ^−/− + VEH) or fenofibrate chow (Vldlr ^−/− + feno). Representative images of immunohistochemistry show the expression of (C) vimentin, (D) alpha-smooth muscle actin (α-SMA), and (E) collagen-1 in the eyecups of Vldlr ^−/− + VEH or Vldlr ^−/− + feno mice. Levels of (F,G) vimentin, (F,H) α-SMA, (F,I) collagen-1, and (F,J) fibronectin were determined by Western blot analysis and quantified by densitometry in the eyecups of Vldlr ^−/− + VEH or Vldlr ^−/− + feno mice (mean ± SEM; n = 8. **p < 0.01 and ***p < 0.001).