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. 2020 Nov 17;11:580884. doi: 10.3389/fphar.2020.580884

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Copyright © 2020 Chen, Jiang, Zhang, Ye, Liang, Wang, Lin, Zong, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fenofibrate suppresses TGF-β/Smad2/3 signaling in very low–density lipoprotein receptor (Vldlr)^−/− retinas. Protein levels of (A,B) TGF-β2, (A C) TGF-βR2, (D,E) p-Smad2/3, and (D,F) t-Smad2/3 were measured by Western blot analysis and quantified by densitometry in eyecups of wild-type mice and Vldlr ^−/− mice fed with control chow (Vldlr ^−/− + vehicle) or fenofibrate chow (Vldlr ^−/− + feno) (mean ± SEM; n = 8. *p < 0.05, **p < 0.01 and ***p < 0.001).