FIGURE 5.

Fenofibrate reduces connective tissue growth factor (CTGF) expression in very low–density lipoprotein receptor (Vldlr)^−/− retinas. (A) Representative images of immunofluorescence of CTGF in the eye of wild-type mice and Vldlr ^−/− mice fed with control chow (Vldlr ^−/− + vehicle) or fenofibrate chow (Vldlr ^−/− + feno). (B,C) Protein levels of CTGF in the three groups were determined by Western blot analysis and quantified by densitometry. (D) Real-time RT-PCR was performed to quantify relative mRNA levels of CTGF in the three groups (mean ± SEM; n = 8. **p < 0.01 and ***p < 0.001).