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. 2020 Nov 17;11:580884. doi: 10.3389/fphar.2020.580884

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Copyright © 2020 Chen, Jiang, Zhang, Ye, Liang, Wang, Lin, Zong, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fenofibrate suppresses subretinal fibrosis in aged very low–density lipoprotein receptor (Vldlr)^−/− mice. Representative images of immunofluorescence of (A) alpha-smooth muscle actin (α-SMA), (B) vimentin, and (C) collagen-1 in the eye of Vldlr ^−/− mice fed with normal chow (VEH) or fenofibrate chow (Feno). Protein levels of (D,E) fibronectin, (D,F) vimentin, and (D,G) collagen-1 were determined by Western blot analysis and quantified by densitometry (mean ± SEM; n = 4. *p < 0.05 and **p < 0.01).