Figure S4.

In silico identification of TKs that oppose the action of PTPN14 in regulating endosomal phenotype. (a) TKs identified from the endosomics database (Collinet et al., 2010; http://endosomics.mpi-cbg.de/) that play a role in determining endosomal phenotypes. Gene profile data were downloaded as a CSV file, and the candidate genes were ranked by negative Pearson correlation with PTPN14, across the EGF and Transferrin (TF) datasets, or against the EGF dataset only. (b) Z-score profiles of PTPN14 and the five most negatively correlated TKs for each of the EGF-specific endosomal parameters shown, generated using the endosomics database (Collinet et al., 2010).