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. 2020 Dec 26;24(1):101994. doi: 10.1016/j.isci.2020.101994

Figure 4.

Figure 4

Single-cell UMAP analysis of HSPC expression of PU.1, GATA-2, and GATA-1 induced by CLL B cell direct or Transwell co-culture

The relative expression of PU.1, GATA-2, and GATA-1 was overlaid on each individual media (n = 20), TNFα (n = 10), TNFα+anti-TNFα (n = 6), CLL direct co-culture (n = 12), CLL + anti-TNFα direct co-culture (n = 9), CLL Transwell (TW) co-culture (n = 7), and CLL + anti-TNFα TW co-culture (n = 7) in vitro condition UMAP. The expression values and colors of each factor are normalized and relative to themselves. Each point in the UMAP represents a single cell and the total data are comprised of 20 individual experiments.