Table 4.

Effect of Lidocaine, Carbamazepine and Amitriptyline on the Spontaneous Activity and Mechanical Threshold Measured in Mechanonociceptor Fibers From Intact and Lesioned Corneas, 24 to 48 Hours After Lesion With Microkeratome

	Intact Corneas		Injured Corneas
Mechanonociceptors	Before	After	Before	After
Lidocaine
Spontaneous activity (imp/s)	0 ± 0	0 ± 0	0.02 ± 0.02	0.01 ± 0.01
Mechanical threshold (mN)	0.29	0.29	0.34 ± 0.03	0.33 ± 0.03
n	2		18
Carbamazepine
Spontaneous activity (imp/s)	0 ± 0	0 ± 0	0 ± 0	0 ± 0
Mechanical threshold (mN)	0.41 ± 0.13	0.41 ± 0.13	0.7 ± 0.23	0.7 ± 0.23
n	9		14
Amitriptyline
Spontaneous activity (imp/s)	0 ± 0	0 ± 0	0 ± 0	0 ± 0
Mechanical threshold (mN)	0.28 ± 0.05	0.28 ± 0.05	0.3 ± 0.05	0.3 ± 0.05
n	5		3-5

Data are mean ± SEM of the values obtained before and after topical application of the corresponding drug during 10 minutes; n = number of explored fibers. No significant differences between the groups were found.