Table 3.
Accuracy of the ICD-10-CM claims-based definitions
| Claims-based definition | Prevalence % (95% CI) | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|---|
| Epilepsy (G40 only)a | 93.0 (91.0–95.4) | 84.4 (80.8–87.5) | 79.4 (62.1–91.3) | 98.3 (96.6–99.3) | 26.2 (18.0–35.8) |
| Epilepsy (G40 and/or R56)b | 93.0 (91.0–95.4) | 97.7 (91.0–95.4) | 44.1 (27.2–62.1) | 96.2 (94.2–97.7) | 57.7 (36.9–76.6) |
| Focal seizuresc,d | 66.0 (62.0–70.3) | 69.8 (64.4–74.8) | 79.4 (72.4–85.3) | 86.8 (82.1–90.7) | 57.5 (50.8–64.0) |
| Generalized seizurese,f | 36.1 (29.5–43.2) | 36.1 (29.5–43.2) | 95.4 (92.3–97.5) | 84.9 (75.5–91.7) | 67.8 (62.9–72.3) |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; Sn, sensitivity; Sp, specificity.
a
Sn=410/486, Sp=27/34;
b
Sn=475/486, Sp=15/34;
c
encounters with ICD-10-CM codes suggestive of focal versus generalized or unknown seizures;
d
Sn=224/321, Sp=131/165
e
encounters with ICD-10-CM codes suggestive of generalized versus focal or unknown seizures;
f
Sn=73/202, Sp=271/284.
Performance metrics of ICD-10-CM claims-based definitions in classifying diagnosis of epilepsy and seizure types against reference-standard documentation in patient EHRs.