Table 1.
Rat Spermatogonial Gene Expression during Culture in SG versus SD MEDIUM
| RNAs Enriched in Rat USg versus DSg |
RNAs Enriched in Rat DSg versus USg |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Protein Coding Gene | Mean TPM |
Species | Protein Coding Gene | Mean TPM |
Species | ||||
| USg | DSg | Spc | USg | DSg | Spc | ||||
| Upk1b | 202 | 4 | 3 | R | Cyp26a1 | 1 | 131 | 2 | R |
| Sgk1 | 184 | 9 | 65 | R | Kcnd2 | 1 | 29 | 4 | R |
| Ctsh | 704 | 45 | 127 | R M | Nphs1 | 1 | 23 | 2 | R |
| Meox1 | 108 | 5 | 1 | R | Mpped2 | 5 | 87 | 11 | R |
| Foxa2 | 107 | 4 | 4 | R Ma | Kit | 39 | 363 | 36 | R M Hc |
| Hmha1 | 169 | 9 | 7 | R M | Polq | 3 | 25 | 25 | R |
| Hoxc4 | 83 | 6 | 3 | R | Ctgf | 3 | 25 | 46 | R |
| Apoe | 572 | 24 | 840 | R M | Kirrel2 | 1 | 19 | 1 | R |
| Irx2 | 59 | 3 | 4 | R H | Erbb3 | 6 | 47 | 5 | R H |
| Gfra2 | 83 | 7 | 2 | R M | Lonrf3 | 38 | 257 | 43 | R M |
| Lhx1 | 72 | 2 | 2 | R M | Elovl2 | 2 | 15 | 37 | R |
| Spry4 | 130 | 16 | 40 | R M | Foxn4 | 3 | 26 | 2 | R M |
| Fgfr3 | 225 | 29 | 5 | R H | Baz1a | 21 | 132 | 293 | R M H |
| Tcl1a | 183 | 18 | <1 | R Hb | Mob1b | 21 | 134 | 69 | R |
| Adgrg1 | 91 | 9 | 66 | R M | Nrcam | 1 | 8 | 6 | R M |
| Lbp | 104 | 9 | 3 | R | Slc35c1 | 3 | 25 | 25 | R |
| Noto | 148 | 5 | 2 | R | Cyp26b1 | 5 | 36 | 8 | R |
| Cited2 | 119 | 14 | 416 | R M H | Rarb | 2 | 33 | 2 | R |
| Frzb | 58 | 2 | 1 | R M | Ngfr | 1 | 11 | 10 | R |
| Cldn4 | 117 | 10 | 5 | R | Igfbp2 | 77 | 582 | 58 | R M Hc |
| Snap91 | 118 | 15 | 3 | R M | Trove2 | 7 | 40 | 32 | R H |
| Dusp4 | 156 | 12 | 18 | R M H | Fmo2 | <1 | 7 | 5 | R |
| Ier3 | 138 | 19 | 939 | R M | Nr0b1 | <1 | 6 | 3 | R |
| Tnfsf12 | 81 | 5 | 12 | R M | Ankrd34b | 6 | 35 | 3 | R |
| Gfra1 | 102 | 15 | 2 | R M H | Dynlt3 | 3 | 22 | 27 | R |
| Phlda1 | 64 | 9 | 92 | R M | Dclre1c | 7 | 42 | 13 | R |
| Mest | 150 | 22 | 5 | R Hb | Ero1a | 31 | 163 | 47 | R |
| Enc1 | 227 | 38 | 36 | R | Tfcp2l1 | 2 | 11 | 10 | R |
| Rcn3 | 107 | 10 | 91 | R M | Kiaa0513 | 4 | 22 | 14 | R |
| Rnf125 | 63 | 7 | 12 | R | Tc2n | 6 | 42 | 36 | R M H |
| Igsf21 | 127 | 11 | 1 | R M | Stra6 | 1 | 10 | 4 | R |
| Ret | 212 | 39 | 7 | R M | Cpne7 | 2 | 18 | 2 | R, Hc |
| Gpx2 | 108 | 8 | 7 | R | Mmd2 | 1 | 7 | 24 | R |
| T | 36 | 3 | 3 | R M | Tbx3 | 15 | 86 | 22 | R |
| Fblim1 | 77 | 10 | 14 | R M | Zfp763 | 2 | 11 | 3 | R M |
| Egr3 | 85 | 4 | 42 | R M | Hist1h1d | 357 | 1726 | 1227 | R |
| Penk | 441 | 14 | 1094 | R M | Tgfbr1 | 12 | 65 | 50 | R |
| Tfap2c | 83 | 7 | 1 | R | Ncoa1 | 14 | 62 | 51 | R M |
Transcripts per Million Kb (Mean TPM values, Table S1) from rat undifferentiated spermatogonia (USg), differentiating spermatogonia (DSg), and spermatocyte (Spc) cultures (n = 2 rats/cell population). Left: R = Rat, enriched >7-fold in USg versus DSg, P < 5e-10; M = Mouse, enriched >2-fold in GFP-ID4 Bright versus GFP-ID4 Dim spermatogonia, p < 0.02.
aFPKM <1 in Mouse GFP-ID4 Bright spermatogonia (Helsel et al., 2017b); H=Human, enriched in spermatogonial transition gene clusters 1 > 2 upb or 1 > 2 down (Guo et al., 2018). Right: R = Rat, enriched >3-fold in DSg versus USg, P < 5 × 10−5; M = Mouse, enriched >2-fold in GFP-ID4 Dim versus GFP-ID4 Bright spermatogonia, p < 0.02; H=Human, enriched in spermatogonial transition gene clusters 2 > 3 up or 2 > 3 downc.