. 2020 Sep 17;246(1):40–47. doi: 10.1177/1535370220958610

Table 2.

Reactome pathways for genes which lost significance of correlation to GATA3 in mutant GATA3 subset.

Negatively correlated genes			Positively correlated genes
Pathway name	P-value	FDR^a	Pathway name	P-value	FDR^a
Regulation of TP53 Expression	2.83e-06	9.21e-04	Attenuation phase	3.33e-15	4.56e-13
RUNX3 regulated CDKN1ATranscription	1.13e-05	0.002	HSF1-dependent transactivation	1.62e-14	1.10e-12
Signaling by interleukins	1.96e-05	0.002	Regulation of HSF1-mediated heat shock response	1.51e-12	6.79e-11
			Cellular response to heat stress	5.21e-12	1.77e-10
			HSF1 activation	1.95e-10	5.26e-09
			Cellular responses to stress	2.73e-09	6.01e-08
			Cellular responses to externalStimuli	3.49e-09	6.64e-08
			Polo-like kinase-mediated events	1.70e-04	0.003
			G1/S transition	2.39e-04	0.004
			Mitotic G1-G1/S phases	3.63e-04	0.005
			G1/S-specific transcription	5.89e-04	0.007
			Cell cycle, mitotic	9.79e-04	0.011
			TP53 regulates transcription of cell cycle genes	0.001	0.013
			HSP90 chaperone cycle for steroid hormone receptors (SHR)	0.002	0.014

^aMinimum significant FDR = 0.05.