Figure 7.

Repression of Wnt/β-catenin signaling blocked the effects of SNHG1 in modulating the tumor-suppressive roles of baicalein. (a) HeLa cells overexpressing SNHG1 were treated with 100 μM baicalein and 25 μM ICG-001 for 24 h, followed by Glo cell viability assay to detect cell viability. (b) HeLa cells overexpressing SNHG1 were treated with 100 μM baicalein and 25 μM ICG-001 for 24 h, followed by EdU incorporation assay to detect cell viability. (c) SNHG1 stably overexpressed HeLa cells were treated with 100 μM baicalein and 25 μM ICG-001 for 24 h, followed by TUNEL assay to measure cell apoptosis. (d) Cell migration of HeLa cells overexpressing SNHG1 and simultaneous treatment with 50 μM baicalein and 12.5 μM ICG-001 for 48 h was detected by transwell migration assay. Results are shown as mean ± SD. Scale bars, 100 µm. **P < 0.01, ***P < 0.001, ns: not significant. (A color version of this figure is available in the online journal.)