Fig. 1.

Schematic diagram depicting high ACE-2-containing brain regions with mechanisms of neuroinvasion by SARS-CoV-2. a Brain regions with high ACE-2 expression. b Hematogenous spread through blood brain barrier. c Transcribrial path from olfactory receptor to brain, followed by activation of inflammation. AP area postrema, BV blood vessels, DNV dorsal motor nucleus of vagus, NH neurohypophysis, NTS nucleus tractus solitarius, OLVT organum vasculosum of the lamina terminalis, PG pineal gland, SCO subcommissural organ, SFO subfornical organ, SN substantia nigra