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Effects of miR-665 and HMGB1 on the activity of the Wnt/β-catenin pathway. Relative protein levels of β-catenin, cyclin D1 and C-myc were measured using western blotting. *P<0.05 vs. control, #P<0.05 vs. pcDNA3.1-HMGB1. HMGB1, high motility box group 1; miR, microRNA.