Table III.
Features of patients with GISTs of heterogenous morphology, immunostaining and genotype.
| Expression | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case no. | Sex | Age (years) | Case part | Site | Morphology | Mitoses (/50HPF)a | CD117 | DOG1 | CD34 | Ki67 (%) | KIT mutation | PDGFRA mutation |
| 1 | F | 66 | A | Greater curvature of the stomach | Spindle | 4 | (+) | (+) | (+) | 5 | Exon 11 p.V560D | WT |
| B | Lesser curvature of the stomach | Epithelioid | 1 | (−) | (+) | (+) | 2 | WT | WT | |||
| 2 | M | 70 | A | Posterior of the gastric fundus | Mixed | 2 | (+) | (−) | (+) | 4 | Exon 11 p.W557R | WT |
| B | Greater curvature of the stomach | Spindle | 5 | (+) | (+) | (+) | 5 | Exon11 p.W557_K558 del | WT | |||
| 3 | F | 82 | A | Stomach | Spindle | 26 | (+) | (+) | (+) | 20 | Exon 11 p.P551_Q556 del | WT |
| B | Omentum | Spindle | 40 | (+) | (+) | (+) | 40 | Exon 11 p.P551_Q556 del | WT | |||
| 4 | M | 83 | A | Abdominal cavity | Mixed | 12 | (+) | (+) | (−) | 25 | Exon 11 p.T574_Q575 insP | WT |
| B | Small intestine | Mixed | 12 | (+) | (+) | (−) | 20 | Exon 11 p.T574_Q575 insP | WT | |||
| 5 | M | 71 | A | Stomach | Mixed | 25 | (+) | (+) | (+) | 40 | Exon 11 p.V555-V559del | WT |
| B | Omentum | Spindle | 20 | (+) | (+) | (+) | 30 | Exon 11 p.Q556-V560del | WT | |||
| 6 | F | 39 | A | Stomach | Mixed (pleomorphic) | 6 | (+) | (+) | (−) | 5 | Exon 11 p.D579del | WT |
| B | Between stomach and spleen | Spindle | 1 | (+) | (+) | (+) | 3 | Exon 11 p.W557G | WT | |||
a
Equal to 5 mm2. GISTs, gastrointestinal stromal tumors; HPF, high-power fields; DOG1, discovered on GIST-1; KIT, KIT proto-oncogene, receptor tyrosine kinase; PDGFRA, platelet derived growth factor receptor α; F, female; M, male; WT, wild-type.