Table IV.
Univariate and multivariate analysis of clinicopathological features and mutational status affecting the RFS of patients with GISTs (n=259).
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Sex | ||||
| Male | 1.0 (reference) | 1.0 (reference) | ||
| Female | 0.412 (0.195-0.873) | 0.021 | 0.694 (0.303-1.587) | 0.387 |
| Age (years) | ||||
| ≤60 | 1.0 (reference) | 1.0 (reference) | ||
| >60 | 1.229 (0.606-2.489) | 0.568 | 1.848 (0.872-3.914) | 0.109 |
| Site | ||||
| Gastric | 1.0 (reference) | 1.0 (reference) | ||
| Non-gastric | 3.383 (1.629-7.025) | 0.001 | 2.420 (1.116-5.251) | 0.025 |
| Morphology | ||||
| Mixed | 1.0 (reference) | 1.0 (reference) | ||
| Spindle | 0.351 (0.142-0.870) | 0.024 | 0.911 (0.352-2.357) | 0.847 |
| Epithelioid | 3.293 (0.914-11.865) | 0.068 | 2.605 (0.578-11.728) | 0.212 |
| Risk stratification | ||||
| Very low/low | 1.0 (reference) | 1.0 (reference) | ||
| Intermediate/high | 10.359 (3.147-34.101) | <0.001 | 3.528 (0.772-16.135) | 0.104 |
| WHO grade | ||||
| 1/2/3a/4 | 1.0 (reference) | 1.0 (reference) | ||
| 3b/5/6a/6b | 9.125 (3.930-21.187) | <0.001 | 3.166 (1.033-9.708) | 0.044 |
| KIT mutation | ||||
| Other mutations | 1.0 (reference) | 1.0 (reference) | ||
| KIT del 557/558/559 | 2.722 (1.235-6.003) | 0.013 | 2.794 (1.204-6.482) | 0.017 |
| WT | 1.126 (0.385-3.298) | 0.828 | 2.087 (0.586-7.432) | 0.256 |
RFS, relapse-free survival; GISTs, gastrointestinal stromal tumors; HR, hazard ratio; CI, confidence interval; WHO, World Health Organization; KIT, KIT proto-oncogene, receptor tyrosine kinase; WT, wild-type.