Table V.
Univariate and multivariate analysis of clinicopathological features and mutational status affecting the RFS of patients with gastric GISTs (n=168).
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Sex | ||||
| Male | 1.0 (reference) | 1.0 (reference) | ||
| Female | 0.318 (0.082-1.232) | 0.097 | 0.407 (0.090-1.835) | 0.242 |
| Age (years) | ||||
| ≤60 | 1.0 (reference) | 1.0 (reference) | ||
| >60 | 1.757 (0.453-6.810) | 0.415 | 3.615 (0.684-19.108) | 0.130 |
| Morphology | ||||
| Mixed | 1.0 (reference) | 1.0 (reference) | ||
| Spindle | 0.219 (0.044-1.087) | 0.063 | 0.319 (0.058-1.753) | 0.189 |
| Epithelioid | 4.072 (0.559-29.678) | 0.166 | 6.279 (0.628-62.802) | 0.118 |
| KIT mutation | ||||
| Other mutations | 1.0 (reference) | 1.0 (reference) | ||
| KIT del 557/558/559 | 12.832 (1.602-102.768) | 0.016 | 9.820 (1.142-84.484) | 0.037 |
| WT | 1.612 (0.101-25.789) | 0.736 | 0.855 (0.044-16.666) | 0.918 |
RFS, relapse-free survival; GISTs, gastrointestinal stromal tumors; HR, hazard ratio; CI, confidence interval; WHO, World Health Organisation; KIT, KIT proto-oncogene, receptor tyrosine kinase; WT, wild-type.