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. 2020 Dec 20;21(2):137. doi: 10.3892/ol.2020.12398

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — miR-200a and miR-141 synergistically inhibit the proliferation, migration and invasion of liver cancer cells. (A) The GV309 vector map is shown (left panel) and the levels of miR-200a (middle panel) and miR-141 (right panel) were detected using reverse transcription-quantitative PCR in stable cell lines overexpressing miR-200a, miR-141 or miR-negative control. (B) The morphological changes of HepG2/miR-NC, HepG2/miR-200a, HepG2/miR-141 and HepG2/miR-200a+miR-141 were observed by microscope (magnification, ×100). (C) The effects of miR-200a, miR-141 and miR-200a+miR-141 overexpression on cell proliferation were analyzed using a Cell Counting Kit-8 assay. (D) Transwell assay was used to measure cell migration in each stable cell line. (E) Transwell assay was used to measure cell invasion in each stable cell line (magnification, ×100; Nikon TE2000). *P<0.05; **P<0.01, ***P<0.001. miR, microRNA.