Table I.
Characteristics of patients with malignant pleural mesothelioma analyzed for Se-SMRP.
| Patient characteristic | n (%) |
|---|---|
| Age, years, at diagnosis, median (range) | 73 (60–90) |
| Sex | |
| Male | 55 (91.6) |
| Female | 5 (8.4) |
| Smoking habit | |
| Non-smoker | 28 (46.7) |
| Current/former smoker | 32 (53.3) |
| Asbestos exposure | |
| Unexposed | 21 (35.0) |
| Exposed | 39 (65.0) |
| Symptoms | |
| Dyspnea | 35 (58.3) |
| Chest pain | 16 (26.7) |
| Unknown | 9 (15.0) |
| IMIG stage | |
| I | 26 (43.3) |
| II | 18 (30.0) |
| III/IV | 15 (25.0) |
| Unknown | 1 (1.7) |
| ECOG-PS | |
| 0 | 26 (43.3) |
| 1 | 22 (36.7) |
| 2/3 | 12 (20.0) |
| Granulocyte/lymphocyte ratio, median (range) | 3.0 (0.1–40.1) |
| <2.70 | 23 (38.3) |
| 2.70–4.13 | 16 (26.7) |
| >4.13 | 21 (35.0) |
| Platelet count, ×103/µl, median (range) | 285 (119–857) |
| <245 | 18 (30.0) |
| 245–317 | 23 (38.3) |
| >317 | 19 (31.7) |
| Histological subtype | |
| Epithelioid | 43 (71.7) |
| Sarcomatoid | 11 (18.3) |
| Biphasic | 6 (10.0) |
| Chemotherapy | |
| Yes | 33 (55.0) |
| No | 13 (21.7) |
| Unknown | 14 (23.3) |
| Se-SMRP, nM, median (range) | 1.24 (0.05–13.5) |
| <0.66 | 17 (28.3) |
| 0.66–1.46 | 18 (30.0) |
| >1.46 | 25 (41.7) |
| Whole sample | 60 (100.0) |
IMIG, International Mesothelioma Interest Group staging system adopted by the American Joint Commission on Cancer (AJCC) in the sixth edition of its Cancer Staging Manual and by the International Union Against Cancer (UICC); ECOG-PS, Eastern Cooperative Oncology Group-performance status; Se-SMRP, serum soluble mesothelin-related protein. All data are presented as n (%) unless otherwise stated.