Table 2.

Univariate and Multivariate Analysis of Prognostic Factors

Factor	Group	n	Univariate analysis		Multivariate analysis
			Median survival	p-value	Odds ratio (95% CI)	p-value
Age (year)	<77	87	68.3 (50.6-79.8)	0.0554	1.01 (0.98-1.05)	0.53
	≥77	23	34.0 (18-51)
Gender	Female	20	79.8 (18-NA)	0.832
	Male	90	58.0 (40-77.6)
Diabetes mallitus	Negative	68	65.8 (36.5-79.8)	0.847
	Positive	42	56.6 (37-86)
HCV	Negative	47	68.3 (40-97.0)	0.79
	Positive	63	58.0 (36.5-79.8)
HBV	Negative	96	58 (40-72)	0.28
	Positive	14	NA (8-NA)
Alcohol abuse	Negative	66	43.0 (25.8-72)	0.166
	Positive	44	68.3 (56.6-97.0)
Albumin (g/L)	<35	21	25 (18.7-50.6)	<0.001	2.37 (1.15-4.89)	0.019
	≥35	89	71 (51-97.0)
ALT (IU/L)	<30	43	43 (32.6-86)	0.604
	≥30	67	66 (44-79.8)
AST (IU/L)	<40	52	72 (43-97.0)	0.116
	≥40	58	44 (24.7-68.3)
Total bilirubin (µmol/L)	<12	47	77.8 (37-NA)	0.222
	≥12	63	58.0 (36.5-71)
Platelet count (x109/L)	<160	54	58.0 (37-86)	0.997
	≥160	56	60.6 (36.3-79.8)
Prothrombin activity (%)	<90	62	60.0 (37-79.8)	0.98
	≥90	48	65.8(34-102.1)
ICGR15 (%)	<20	83	71.0 (43-86)	0.0921	1.12 (0.63-2.01)	0.7
	≥20	27	40.5 (19.5-68.3)
Child Pugh	A	96	66.0 (43-79.8)	0.0711	1.13 (0.46-2.73)	0.79
	B	14	33.5 (18-NA)
Tumor type	Simple nodular	55	66.0 (41.3-79.8)	0.635
	Others	55	50.6 (25-86)
Tumor site	Unilateral	75	58 (36.3-77.6)	0.492
	Bilateral	35	72 (37-97.0)
AFP (g/L)	<100	62	86 (66-NA)	<0.001	2.83 (1.68-4.76)	<0.001
	≥100	48	34 (21-41.3)
PIVKA-II (mAU/mL)	<100	39	79.8 (56.6-NA)	0.0373	1.40 (0.78-2.50)	0.26
	≥100	71	41.3 (32.6-71)
Tumor size (cm)	<5	61	77.6 (50.6-102.1)	0.0326	1.33 (0.78-2.28)	0.29
	≥5	49	43 (25.8-65.8)
Tumor number	<4	86	60.6 (41.3-79.8)	0.693
	≥4	24	56.6 (23.2-NA)

HBV, hepatitis B virus; HCV, hepatitis C virus; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ICGR15, indocyanine green retention rate at 15 minutes; AFP, α-fetoprotein; PIVKA-II, protein induced by vitamin K absence or antagonist-II