Table 1.
Association between VDR Polymorphisms and Risk for Cervical Cancer
| Genotypes/Alleles | Control n (%) | Case n (%) | Crude OR [95%CI, p] | Adjusted ORb [95%CI, p] |
|---|---|---|---|---|
| Fok1 a | ||||
| CC | 55 (29.6) | 45 (22.06) | 1 | 1 |
| CT | 106 (51.96) | 96 (47.06) | 1.11 [0.67-1.84, 0.6790] | 1.44 [0.71-2.94, 0.313] |
| TT | 43 (21.08) | 63 (30.88) | 1.79 [1.03-3.11, 0.0388*] | 2.66 [1.17-6.04, 0.020*] |
| CT+TT | 149 (73.04) | 159 (77.94) | 1.3 [0.81-2.11, 0.2498] | 1.77 [0.90-3.46, 0.096] |
| C | 0.53 | 0.46 | 1 | 1 |
| T | 0.47 | 0.54 | 1.34 [1.02-1.77, 0.0357*] | NA |
| Apa1 a | ||||
| GG | 100 (49.02) | 94 (46.08) | 1 | 1 |
| GT | 83 (40.69) | 82 (40.2) | 1.05 [0.68-1.63, 0.8143] | 1.11 [0.61-2.04, 0.728] |
| TT | 21 (10.29) | 28 (13.73) | 1.42 [0.72-2.82, 0.2771] | 1.96 [0.79-4.84, 0.144] |
| GT+TT | 104 (50.98) | 110 (53.92) | 1.13 [0.75-1.69, 0.5520] | 1.27 [0.72-2.24, 0.410] |
| G | 0.69 | 0.66 | 1 | 1 |
| T | 0.31 | 0.34 | 1.16 [0.86-1.55, 0.3302] | NA |
| Taq1 a | ||||
| TT | 133 (65.2) | 88 (43.14) | 1 | 1 |
| TC | 58 (28.43) | 95 (46.57) | 2.48 [1.59-3.87, 0.0001*] | 2.36 [1.28-4.35, 0.006*] |
| CC | 13 (6.37) | 21 (10.29) | 2.44 [1.10-5.58, 0.0160*] | 2.11 [0.73-6.10, 0.167] |
| TC+CC | 71 (34.8) | 116 (56.86) | 2.47 [1.62-3.76, 0.0001*] | 2.31 [1.30-4.11, 0.004*] |
| T | 0.79 | 0.66 | 1 | 1 |
| C | 0.21 | 0.34 | 1.95 [1.42-2.67, 0.0001*] | NA |
OR, odds ratio, CI: confidence interval, * p < 0.05, NA: not applicable; a no deviation from Hardy–Weinberg equilibrium (p > 0.05 by χ2 test); b adjusted multiple logistic regression for partners’ smoking, contraceptive use and HPV infection